Bayesian Networks for Whole Building Level Fault Diagnosis and Isolation

Buildings consume more than 40% of primary energy in the U.S. and 57% of the energy usage in commercial and residential buildings are consumed by the heating, ventilation and air conditioning (HVAC) system.Malfunctioning sensors, components, and control systems, as well as degrading systems in HVAC and lighting systems are main reasons for energy waste and unsatisfactory indoor environment. In HVAC systems, faults occur in one component or equipmentcan also cause abnormality in other subsystems because of the coupling among different subsystems. Therefore, whole building level fault diagnosis methods is critical to locate fault root cause and isolate the fault. Bayesian network (BN) is a prevalent toolin fault diagnosis which can deal withprobabilistic reasoning of uncertainty. In this paper, a two-layer Bayesian network which consists of fault layer and fault symptom layer is developed to diagnose whole building HVAC system fault. Weather information based Pattern Matching (WPM) method which was employed in fault detection was also used to create baseline data and generate LEAK probability. BAS data from a campus building are collected to evaluate the effectiveness of the proposed method

Satb2 acts as a gatekeeper for major developmental transitions during early vertebrate embryogenesis

Zygotic genome activation (ZGA) initiates regionalized transcription underlying distinct cellular identities. ZGA is dependent upon dynamic chromatin architecture sculpted by conserved DNA-binding proteins. However, the direct mechanistic link between the onset of ZGA and the tissue-specific transcription remains unclear. Here, we have addressed the involvement of chromatin organizer Satb2 in orchestrating both processes during zebrafish embryogenesis. Integrative analysis of transcriptome, genome-wide occupancy and chromatin accessibility reveals contrasting molecular activities of maternally deposited and zygotically synthesized Satb2. Maternal Satb2 prevents premature transcription of zygotic genes by influencing the interplay between the pluripotency factors. By contrast, zygotic Satb2 activates transcription of the same group of genes during neural crest development and organogenesis. Thus, our comparative analysis of maternal versus zygotic function of Satb2 underscores how these antithetical activities are temporally coordinated and functionally implemented highlighting the evolutionary implications of the biphasic and bimodal regulation of landmark developmental transitions by a single determinant

Quantitative whole-tissue 3D imaging reveals bacteria in close association with mouse jejunum mucosa

Raw and processed data and imaging files [0.42 TB total] for the bioRxiv preprint "Quantitative whole-tissue 3D imaging reveals bacteria in close association with mouse jejunum mucosa"Related Publication: Quantitative whole-tissue 3D imaging reveals bacteria in close association with mouse jejunum mucosa bioRxiv engFiles available via S3 at https://renc.osn.xsede.org/ini210004tommorrell/0_D1.20199/DataSummary.xlsx 0.0 GB Download Fig01-DataAnalysis-GrowthCurves.zip 0.0 GB Download Fig01-DataAnalysis-RTqPCR.zip 0.0 GB Download Fig02-DataAnalysis.zip 0.0 GB Download Fig03-DataAnalysis.zip 0.27 GB Download Fig04-Fig06-DataAnalysis.zip 0.07 GB Download FigS07-DataAnalysis.zip 0.29 GB Download FigS08-DataAnalysis.zip 0.64 GB Download FigS09-DataAnalysis.zip 0.23 GB Download FigS11-DataAnalysis.zip 0.0 GB Download R4P-p091-20xC-ImarisSurfaceFiles.zip 0.0 GB Download R4P-p091-D28C3M1-EJ-5x_Stitch.czi 2.69 GB Download R4P-p091-D29C2M1-EJ-5x_Stitch.czi 2.4 GB Download R4P-p091-D29C4M2-EJ-1.czi 6.81 GB Download R4P-p091-D29C4M2-EJ-1.ims 10.38 GB Download R4P-p091-D29C4M2-EJ-3.czi 4.25 GB Download R4P-p091-D29C4M2-EJ-3.ims 7.5 GB Download R4P-p091-D29C4M2-EJ-5x_Stitch.czi 1.82 GB Download R4P-p091-D31C1M1-EJ-5x_Stitch.czi 3.13 GB Download R4P-p121-Bfrag-v3EC-v3BAC-20x.czi 1.43 GB Download R4P-p121-Ecoli-v3EC-v3BAC-20x.czi 1.42 GB Download R4P-p124-20xC-ImarisSurfaceFiles.zip 0.0 GB Download R4P-p124-D28C1M1-EJ-5x_Stitch.czi 0.99 GB Download R4P-p124-D28C2M1-EJ-5x_Stitch.czi 1.31 GB Download R4P-p124-D28C3M1-EJ-1.czi 4.96 GB Download R4P-p124-D28C3M1-EJ-1.ims 6.88 GB Download R4P-p124-D28C3M1-EJ-2.czi 4.8 GB Download R4P-p124-D28C3M1-EJ-2.ims 7.07 GB Download R4P-p124-D28C3M1-EJ-3.czi 3.97 GB Download R4P-p124-D28C3M1-EJ-3.ims 5.96 GB Download R4P-p124-D28C3M1-EJ-5x_Stitch.czi 1.0 GB Download R4P-p124-D28C4M1-EJ-1.czi 4.51 GB Download R4P-p124-D28C4M1-EJ-1.ims 9.0 GB Download R4P-p124-D28C4M1-EJ-2.czi 4.5 GB Download R4P-p124-D28C4M1-EJ-2.ims 6.52 GB Download 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